Resume:

Yanlian Yang, Professor. She received B.S. and M.S. degrees in Chemistry from Shandong University in 1996 and 1999, respectively. In 2002, she obtained PhD degree in Physical Chemistry from Peking University, and then worked as a postdoctoral researcher in Peking University from 2002 to 2004. Since 2004, she joined National Center for Nanoscience and Technology (NCNST). She was a visiting scholar at the Center for Biomedical Engineering, Massachusetts Institute of Technology from 2007 to 2008. She currently is a Professor in NCNST. Her research interests include: structure, modulation and the molecular mechanism of peptide assembly related to degeneration diseases; development of new nano-characterization methods based on scanning probe microscopy; and construction and characterization of functional molecular nanostructures.

Direction:

1)Structure, modulation and the molecular mechanism of peptide assembly related to degeneration diseases;

2)Development of new nano-characterization methods based on scanning probe microscopy;

3)Construction and characterization of functional molecular nanostructures;

Peer Reviewed Papers:

1. Lei Liu, Lin Niu, Meng Xu, Qiusen Han, Hongyang Duan, Mingdong Dong, Flemming Besenbacher, Chen Wang*, Yanlian Yang*, “Molecular tethering effect of C-terminus of amyloid peptide Aβ42”, ACS Nano, 2014, 8(9), 9503-9510.

2. Xiaobo Mao, Yuanyuan Guo, Yin Luo, Lin Niu, Lei Liu, Xiaojing Ma, Huibin Wang, Yanlian Yang*, Guanghong Wei*, Chen Wang*, “Sequence Effects on Peptide Assembly Characteristics Observed by Using Scanning Tunneling Microscopy” J. Am. Chem. Soc. 2013, 135 (6), 2181–2187.

3. Min Zhang, Xiaobo Mao, Yue Yu, Chenxuan Wang, Xiaobo Mao, Yanlian Yang,* Chen Wang* “Nanomaterials for reducing amyloid cytotoxicity”, Adv. Mater., 2013, 2013, 25(28), 3780–3801.

4. Min Zhang, Xiaobo Mao, Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang,* Wei Liang*, Chen Wang*, “The Effect of Graphene oxide on Conformation Change, Aggregation and Cytotoxicity of HIV-1 Regulatory Protein (Vpr)”, Biomaterials, 2013, 34(4), 1383-1390.

5. Xiaobo Mao, Chenxuan Wang, Xingkui Wu, Xiaojing Ma, Lei Liu, Lan Zhang, Lin Niu, Yuanyuan Guo, Denghua Li, Yanlian Yang*, Chen Wang*, “Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies” Proc. Natl. Acad. Sci. USA. 2011, 108(49), 19605-19610.

6. Lei Liu, Lan Zhang, Lin Niu, Meng Xu, Xiaobo Mao, Yanlian Yang*, Chen Wang*, “Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-like Molecules” ACS Nano, 2011, 5(7), 6001-6007.

7. Yanlian Yang, Chen Wang*, Hierarchical construction of self-assembled low-dimensional molecular architectures observed by using scanning tunneling microscopy, Chem. Soc. Rev., 2009, 38, 2576-2589.

8. Lei Liu, Lan Zhang, Xiaobo Mao, Lin Niu, Yanlian Yang,* and Chen Wang* “Chaperon-Mediated Single Molecular Approach Toward Modulating Abeta Peptide Aggregation” Nano Lett., 2009, 9(12), 4066-4072.

9. Yanlian Yang, Ulung Khoe, Xiumei Wang, Akihiro Horii, Hidenori Yokoi and Shuguang Zhang* “Designer Self-assembling Peptide Nanomaterials”, Nano Today, 2009, 4, 193-210.

10. Yanlian Yang, Qilin Chan, Xiaojing Ma, Yongtao Shen, Ke Deng, Xizeng Feng*, Chen Wang*, Electrical Conformational Bistability of Dimesogen Molecules with a Molecular Chord Structure”, Angew. Chem. Int. Ed., 2006, 45, 6889-6893.