Prof. HAO WANG

National Center for Nanoscience and Technology of China (NCNST)， Beijing

CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety

Zhongguancun, Beiyitiao No. 11 Beijing 100190, China

Tel: +86-10-8254 5759

Email: wanghao@nanoctr.cn

Homepage: http://www.nanoctr.cn/wanghao

CURRENT RESEARCH INTERESTS

My research interests are to develop supramolecular materials for the advancement of molecular diagnostics (imaging) and therapeutics, as well as in vitro molecular diagnostics. We envision that the combination of modular molecular assembly strategy and modern in vivo molecular diagnostics/therapeutics and in vitro molecular diagnostics represents an important paradigm shift for drug discovery and clinical patient management applications.

QUALIFICATIONS/ADVISORS

2011-present Professor, National Center for Nanoscience and Technology of China

2010-2011 Staff Research Associate, Department of Molecular and Medical Pharmacology, UCLA

2007-2010 Postdoctoral Fellow, Department of Molecular and Medical Pharmacology, UCLA

2006 - 2007 Alexander von Humboldt (AvH) Fellow, University Würzburg, Germany.

2000 -2005 Ph. D. at Department of Chemistry, Nankai University, China.

1996 - 2000 B.S. at the Department of Chemistry, Nankai University, China.

Graduate Advisor Prof. Yu Liu (Nankai University)

Postdoctoral Advisor Prof. Frank Würthner (University Würzburg, Germany)

Prof. Hsian-Rong Tseng (UCLA)

AWARDS AND HONORS

Adjunct Professor，East China University of Science and Technology, 2011-2014

Excellent Ph. D. Thesis Award in Tianjin, 2007

Nomination National Top 100 Excellent Ph. D. Thesis Award in China, 2007

Alexander von Humboldt Fellowship in 2005-2007

Scholarship of Chinese Academy of Science in 2004

“Yang Shi-xian” award in 2004.

“Top 10 Graduates of Nankai University” award in 2004.

PUBLICATIONS

[1].Molecular Structural Transformation Regulated Dynamic Disordering of Co-Assembly Constructed by pH responders and Liposome: Tumor Environment Responsive Drug Release Systems

Ya Liu, Fu-Ping Gao, Di Zhang, Yun-Shan Fan, Xi-Guang Chen* and Hao Wang*

Biomaterials, 2013, Submitted.

[2]. Magneto-Controllable Capture and Release of Cancer Cells by Using a Micropillar Device Decorated with Graphite Oxide-Coated Magnetic Nanoparticles

Xiaolei Yu, Rongxiang He, Shasha Li, Bo Cai, Libo Zhao, Lei Liao, Wei Liu, Qian Zeng, Hao Wang, Shi-Shang Guo,* and Xing-Zhong Zhao

Small, 2013, DOI:10.1002/smll.201300169

[3]. On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

Jae-Hyun Lee, Kuan-Ju Chen, Seung-Hyun Noh, Mitch Andra Garcia, Hao Wang, Wei-Yu Lin, Heeyeong Jeong, Brian Junoh Kong, David B. Stout, Jinwoo Cheon,* and Hsian-Rong Tseng*

Angew. Chem. Int. Ed., 2013, 52, 4384-4388.

[4]. Enzyme-Coated Mesoporous Silica Nanoparticles as Efficient Anti-bacterial Agents In Vivo

Li Lili and Hao Wang*

Adv. Healthcare Mater. 2013, in press.

[5]. The Therapeutic Efficacy of Camptothecin-Encapsulated Supramolecular Nanoparticles

Kuan-Ju Chen, Li Tang, Mitch A. Garcia , Hao Wang , Hua Lu , Wei-Yu Lin , Shuang Hou, Qian Yin , Clifton K.-F. Shen, Jianjun Cheng*, Hsian-Rong Tseng*

Biomaterials, 2012, 33, 1162-1169.

[6].Delivery of Intact Transcription Factor Using Self-Assembled Supramolecular Nanoparticles

Yang Liu, Hao Wang*, Ken-ichiro Kamei, Ming Yan, Kuan-Ju Chen, Linqi Shi*, Yunfeng Lu*, and Hsian-Rong Tseng*

Angew Chem. Int. Ed. 2011, 50, 3058-3062. (Corresponding author)

Selected as "VIP" paper

[7]. An MRI Contrast Agent Library: Effective Optimization of Gd(III)-Encapsulated Supramolecular Nanoparticles for Improved Relaxivity and Sensitivity

Kuan-Ju Chen, Stephanie M. Wolahan, Hao Wang, Chao-Hsiung Hsu, Hsing-Wei Chang, Lian-Pin Hwang, Mitch A. Garcia, Ziyue Karen Jiang, Lily Wu, Yung-Ya Lin*, Hsian-Rong Tseng*

Biomaterials, 2011, 32, 2160-2165.

[8]. A Rapid Pathway Toward a Superb Gene Delivery System: Programming Structural and Functional Diversity into a Supramolecular Nanoparticle Library

Hao Wang, Kan Liu, Kuan-Ju Chen, Yujie Lu, Shutao Wang, Wei-Yu Lin, Feng Guo, Ken-ichiro Kamei, Yi-Chun Chen, Minori Ohashi, Mingwei Wang, Mitch André Garcia, Xing-Zhong Zhao, Clifton K.-F. Shen*, Hsian-Rong Tseng*

ACS Nano, 2010, 4, 6235-6243. (Cover paper)

Press release: UCLA newsroom, UCLA weekly news, CNSI news.

Highlight: Lab on a Chip

[9]. A Digital Microfluidic Droplet Generator Produces Self-assembled Supramolecular Nanoparticles for Targeted Cell Imaging

Kan Liu*, Hao Wang*, Kuan-Ju Chen, Feng Guo, Wei-Yu Lin, Yi-Chun Chen, Duy Linh Phung, Hsian-Rong Tseng* and Clifton K.-F. Shen*

Nanotechnology, 2010, 21, 445603-445610. (Corresponding author).

Highlight: Nanotechweb from IOP publishing

[10]. Photothermal Effects of Supramolecularly Assembled Gold Nanoparticles for the Targeted Treatment of Cancer Cells

Shutao Wang, Kuan-Ju Chen, Ting-Hsiang Wu, Hao Wang, Wei-Yu Lin, Minori Ohashi, Pei-Yu Chiou*, Hsian-Rong Tseng*

Angew Chem. Int. Ed. 2010, 49, 3777-3781.

Highlight: National Cancer Institute (NCI) news

[11]. Three-Dimensional Nanostructured Substrates for Highly Efficient Capture of Circulating Tumor Cells

Shutao Wang*, Hao Wang, Ken-ichiro Kamei, Kuan-Ju Chen, Jing Sun, David J. Sherman, Christian P. Behrenbruch*, and Hsian-Rong Tseng*

Angew Chem. Int. Ed. 2009, 48, 8970-8973.

Press release: UCLA newsroom, CNSI news, National Cancer Institute (NCI) news

[12]. Unconventional Hydrogen-Bond-Directed H ierarchical Co-Assembly Between Perylene Bisimide and Azobenzene-Functionalized Melamine

Shiki Yagai*, Saori Hamamura, Hao Wang, Vladimir Stepanenko, Tomohiro Seki, Kanako Unoike, Yoshihiro Kikkawa, Takashi Karatsu, Akihide Kitamura and Frank Würthner*

Org. Biomol. Chem., 2009, 7, 3926 - 3929.

Highlights in Chemical Science

[13]. A Supramolecular Approach for Preparation of Size-Controllable Nanoparticles

Hao Wang, Shutao Wang, Helen Su, Kuan-Ju Chen, Amanda Lee Armijo, Wei-Yu Lin, Yanju Wang, Jing Sun, Ken-ichiro Kamei, Johannes Czernin*, Caius G. Radu* and Hsian-Rong Tseng*

Angew Chem. Int. Ed. 2009, 48, 4344-4348.

[14]. Supramolecular Construction of Fluorescence J-Aggregates Based on Hydrogen-Bonded Perylene Dyes

Theo. E. Kaiser, Hao Wang, Vladimir Stepanenko, Frank Würthner*

Angew Chem. Int. Ed. 2007, 46, 5541-5544.

[15]. Supramolecular Aggregates Constructed From Gold Nanoparticles and L-Try-CD Polypseudorotaxenes as a Captor for Fullerenes

Yu Liu*, Hao Wang, Yong Chen, Chen-Feng Ke and Min Liu

J. Am. Chem. Soc. 2005, 127，657-666.

BOOKS

[1].Kuan-Ju Chen, Mitch Andre Garcia, Hao Wang and Hsian-Rong Tseng Supramolecular Nanoparticles for Molecular Diagnostics and Therapeutics. 2012. Supramolecular Chemistry: From Molecules to Nanomaterials. Eds: Philip A. Gale and Jonathan W. Steed, John Wiley & Sons, Ltd. ISBN: 978-0-470-74640-0.

[2]. Yu Liu, Heng-Yi Zhang, Li Li and Hao Wang (2005): Nano-sized Supramolecular Chemistry: From Artificial Receptors to Functional Assemblies (in Chinese). Chemical Industry Press.

PATENTS

[1].Patent Application “A Supramolecular Approach for Preparation of Size-Controllable Nanoparticles.” Pub. No.: WO/2010/099466.

[2]. Patent Application, “3D Nanostructured Substrates for Highly Efficient Capture of Circulating Tumor Cells (CTCs).” Pub. No.: WO/2010/108003.

PROFESSIONAL SOCIETIES

American Association for the Advancement of Science (AAAS)

American Chemical Society (ACS)