Prof. Zhiyuan Hu

huzy@nanoctr.cn

Hu’s lab is focused on in vitro diagnostics for immune diseases based on proteomics and nano technology. We have developed a microfluidic platform for high throughput peptides/peptoids synthesis. We also have developed a method for high throughput peptide on-beads screening based on magnetic beads enrichment, MS sequencing, and Surface Plasmon Resonance imaging (SPRi) chip analysis. The goal is to discover disease specific biomarkers of autoantigens and allergens, then to further develop peptide chip for personal diagnosis for autoimmune and allergy diseases.

Resume:

2011- Professor, National Center for Nanoscience and Technology of China

2007-2010 Research Scientist, Institute for Systems Biology, USA

2006-2007 Postdoctoral Fellow, Institute for Systems Biology, USA

2005-2006 Postdoctoral Fellow, Johns Hopkins University

2000-2005 Ph. D. at Dept. Biological Chemistry, Johns Hopkins University

1990-1995 B.S. at Dept. Genetics, Fudan University, China.

Publications:

1) Sun B, Utleg AG, Hu Z, Qin S, Keller A, Lorang C, Gray L, Brightman A, Lee D, Alexander VM, Ranish JA, Moritz RL, Hood L. Glycocapture-Assisted Global Quantitative Proteomics (gagQP) Reveals Multiorgan Responses in Serum Toxicoproteome.J Proteome Res. (2013);12(5):2034-44

2)Lausted C., Hu Z., Hood L., Label-free detection with surface plasmon resonance imaging. Methods Mol. Biol., 2011, 723:321-33.

3) Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood L, and Galas D. Circulating microRNAs, a new class of blood biomarker for drug- induced liver injury. PNAS. (2009); 106(11): 4402-7

4)Lausted C*, Hu Z*, Hood L. Quantitative serum proteomics from surface plasmon resonance imaging. Mol Cell Proteomics. (2008); 7(12): 2464–2474

5)Hu Z, Hood L and Tian Q. Quantitative Proteomic Approaches for Biomarker Discovery. Proteomics-Clinical Applications. (2007); 1(9): 1036-41

6)Chakravarthy MV, Zhu Y, Lopez M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest. (2007); 117(9): 2539-52

7) Hu Z, Cha SH, van Haasteren G, Wang J and Lane MD. Effect of centrally-administered C75, a FAS inhibitor, on ghrelin secretion and its downstream effects. PNAS. (2005); 102(11): 3972-7

8) Hu Z, Cha SH, Chohnan S, Lane MD. Hypothalamic malonyl-CoA as a mediator of feeding behavior. PNAS. (2003); 100(22): 12624-9